Does Tylenol Show up on a 12-Panel Drug Test?

Generally, Tylenol might not show up in a standard drug test unless specifically tested. But when combined with Codeine, it might show up in your 12-panel drug test as opiates. This might happen if you are taking the medication without a prescription. Tylenol might contain less than 90 milligrams of Codeine in them, making them a schedule III drug that leads to the possibility of showing up even in a standard 5-panel drug test. This blog will help you know about Tylenol and does it show up in your 12-panel drug test.

What is Tylenol?

Tylenol (Acetaminophen) is used to treat muscle pain after a heavy workout, treating fever, and headache. It is an over-the-counter medication, but it should be taken only based on the prescription. It does not lead to any side effects or allergic reactions, but it is better to consult your doctor if it occurs. When taken along with Codeine, it has the potential of driving one to dependency. Codeine is an opiate, and hence it may show up on a 12-panel drug test.

Side Effects of Tylenol

Tylenol, if taken, does not create any side effects unless taken with Codeine. Some of the side effects of Tylenol with Codeine are

  • Constipation
  • Difficulty in urination
  • Drowsiness
  • Nausea
  • Headache
  • Lightheadedness
  • Mood changes
  • Stomach pain
  • Confusion and lack of focus.

If taken with Codeine without prescription, it may lead to dependency and addiction.

Despite being in the safety range, Acetaminophen (Tylenol) might lead to death or overdose if taken more than 3000 milligrams per day. It is best to consult your doctor first rather than taking over-the-counter prescription medicine like Tylenol.

How long can Tylenol stay in your body?

You can feel the effects 3 hours after taking the drug. Tylenol can stay in your urine for about three days to four weeks based on the frequency of usage. It can remain in your blood for 24 to 48 hours, whereas in saliva for 4 to 7 days. Hair has the longest retention period for about 30 to 90 days after the previous usage.

Can you pass your 12-panel drug test when taking Tylenol?

Maybe. As previously said, Tylenol will not show up in your 12-panel drug test unless it is specifically tested for acetaminophen. But you may get positive results if you take Tylenol with Codeine.

How to ward off Tylenol from your body?

It is best to keep yourself away from the drug if you give your Tylenol drug test. You may refrain from combining with Codeine if you are about to give your 12-panel drug test. It is Codeine that may show up in your standard drug test and not Tylenol. You can consult your doctor about your medications.


To conclude, Tylenol might not show up in a standard 12-panel drug test, but when taken with Codeine might show up in your drug screening. So, it is best to take prescription medications and avoid illicit drugs to pass your 12-panel drug test.

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